IN PARTNERSHIP WITH
The competition of the cosmetics industry - Cosmoprof Awards
Icure Pharm & Cosmetics Inc

SKIN FASTING EXOSOME SERUM

Resveratrol exosomes within this longevity serum act to trigger a fasting-mimicking mechanism in the skin to activate biomimetic autophagy, helping skin expel cellular waste. This results in a fortified skin barrier, metabolic efficiency, and a reduction in stress-related dullness. The formula employs a proprietary plant phenolic fraction technology to harness resveratrol exosomes from grape stem cells. By inducing "fasting-mimicking stress" during cultivation, the exosomes are concentrated with high-potency bio-active peptides that trigger the biomimetic autophagy, reducing lipofuscin – or aging waste – and neutralizing DNA damage. Alongside the exosomes’ repair, the formula’s proprietary complex of winter cherry and maca root adaptogens enhance skin's anti-stress resilience and restore homeostasis against fatigue. Meanwhile, the squalane-encapsulation system sees micro-capsules engineered to visually mirror the spherical structure of the exosomes. The capsules’ “burst-on-contact” technology creates a separation between the aqueous actives and protective lipids, for maximum potency and immediate barrier reinforcement.

Hall (Pavilion) and Stand Number: Hall 16A - Stand 42

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This product is a finalist in the category Skin Care Formula of Cosmopack 2026

Product Description (No Prototypes accepted)
Resveratrol exosomes within this longevity serum act to trigger a fasting-mimicking mechanism in the skin to activate biomimetic autophagy, helping skin expel cellular waste. This results in a fortified skin barrier, metabolic efficiency, and a reduction in stress-related dullness. The formula employs a proprietary plant phenolic fraction technology to harness resveratrol exosomes from grape stem cells. By inducing "fasting-mimicking stress" during cultivation, the exosomes are concentrated with high-potency bio-active peptides that trigger the biomimetic autophagy, reducing lipofuscin – or aging waste – and neutralizing DNA damage. Alongside the exosomes’ repair, the formula’s proprietary complex of winter cherry and maca root adaptogens enhance skin's anti-stress resilience and restore homeostasis against fatigue. Meanwhile, the squalane-encapsulation system sees micro-capsules engineered to visually mirror the spherical structure of the exosomes. The capsules’ “burst-on-contact” technology creates a separation between the aqueous actives and protective lipids, for maximum potency and immediate barrier reinforcement.
Launch Worldwide Date (First worldwide launch must have been launched within 12 months prior to the event). Date (Month/Day/Year)
January 2026
Product Innovation
Developed to address the modern fatigue of skin-barrier saturation, we pioneered “high-potency minimalism” focused on biological essentiality. Our process is centered on bridging systemic wellness with topical care, resulting in a proprietary fasting-mimicking mechanism that triggers biomimetic autophagy. We validated this concept through iterative R&D, pairing exosome technology with Winter Cherry and Maca root adaptogens to optimize cellular recycling and anti-stress resilience. This innovative framework creates a manifesto for the fusion of metabolic science and skin longevity, meeting the consumer demand for profound restoration and future-proof, science-led biological health.
Claims & Benefits
This serum delivers a metabolic reset by triggering biomimetic autophagy via Resveratrol Exosomes, purging cellular waste to intercept aging at its source. Beyond repair, it provides a dual-action defense: a proprietary complex of Winter Cherry and Maca root adaptogens enhances the skin's anti-stress resilience, restoring homeostasis against environmental and lifestyle-induced fatigue. Concrete benefits include a fortified skin barrier, optimized metabolic efficiency, and a visible reduction in stress-related dullness. The result is a profound recovery of vitality and a radiant, resilient glow—defining a new standard for longevity by protecting the skin’s biological essentiality against a fast-paced world.
Research, Clinical Tests & Trials Results (Safety & Dermatological)

1. In-vivo: Fasting-mimicking Effect (Skin Roughness) *Test completed
→ Test evaluation demonstrated a progressive reduction in skin roughness, with a -5% improvement at one month (T28) and a
significant -8% decrease by 56 days (T56), effectively refining skin texture
• Caucasian subjects (n=66, aged 40-65), placebo-controlled. Comparison between actual intermittent fasting (12-14 hours) + placebo application versus Resveratrol Exosome
application without fasting. Evaluations conducted on D28 and D56. Resveratrol Exosome 1%, applied twice daily to the entire face. Assessment of wrinkles, roughness, pigmentation
(erythema and melanin), and stratum corneum sampling.

2. In-vivo: Fasting-mimicking Effect (Skin Melanin Index) *Test completed→ Test assessment revealed a sequential decline in the melanin index, with a -4.1% decrease at one month (T28) and a
significant -6.1% attenuation by 56 days (T56), facilitating a visibly more radiant and uniform skin complexion
• Caucasian subjects (n=66, aged 40-65), placebo-controlled. Comparison between actual intermittent fasting (12-14 hours) + placebo application versus Resveratrol Exosome
application without fasting. Evaluations conducted on D28 and D56. Resveratrol Exosome 1%, applied twice daily to the entire face. Assessment of wrinkles, roughness, pigmentation
(erythema and melanin), and stratum corneum sampling.

3. In vitro: Lipofuscin Modulation *Test completed
→ In vitro assays indicate that Resveratrol Exosome suppresses lipofuscin accumulation in a dose-dependent manner, effectively
mitigating the formation of age-associated pigments by enhancing cellular homeostasis
• Human dermal fibroblasts. Progressive ageing for two months
• Control +: Metaformin (Hyoglycemic control) -100µM
• Lipofuscin accumulation
• Sudan black B (SBB) staining. Protocol based on Davan-Wetton et al., 2024

4. In vitro: Reduction in Senescence-Associated β-galactosidase (SA-β-Gal) Activity *Test completed
→ Resveratrol Exosomes effectively attenuate cellular senescence by downregulating the activity of Senescence-Associated
β-galactosidase (SA-β-Gal), a definitive biomarker of cellular aging
• Human dermal fibroblasts. Progressive ageing for two months
• Control +: Kojic Acid 500µM : Metformin (Hypoglyocemic control) ) -100µM
• SA-β-Galactosidase activity
• X-Gal activity detection kit.

Certifications, Patents & Regulatory Compliance
U.S FDA/MOCRA
Ingredients List & Formulation (Mandatory, if not specified disqualification from the contest)
Core Biological Innovation: Utilizing proprietary PPF (Plant Phenolic Fraction) technology, we harness premium Resveratrol Exosomes derived from Spanish Rioja grape stem cells. By inducing "fasting-mimicking stress" during cultivation, we concentrate high-potency bio-active peptides that trigger biomimetic autophagy, effectively reducing Lipofuscin (aging waste) and neutralizing ROS-induced DNA damage. These plant-derived vesicles serve as high-efficiency delivery systems to optimize mitochondrial health and preserve the dermal matrix.
Technology Features
Design Innovation: The Dual-Phase Delivery What makes this product visually and technically special is the Squalane-encapsulation system. Unlike standardized emulsions, these micro-capsules are engineered to visually mirror the spherical structure of the exosomes themselves, creating a tangible connection between the macro-experience and micro-science. This 'burst-on-contact' technology maintains a distinct separation between the aqueous actives and protective lipids, ensuring maximum potency and immediate barrier reinforcement. The Resilience Synergy The integration of Winter Cherry and Maca root adaptogens creates a 'Homeostasis Shield'. This dual-layer innovation—merging high-tech cellular signaling with advanced material design defines a new category in skin longevity, moving beyond traditional care toward a future-proof, science-led health solution.
Sustainability List of Certifications
All ingredients are formulated as 100% vegan, containing no animal-derived components, and were developed in full compliance with global cosmetic regulations prohibiting animal testing
How to use it
Apply an appropriate amount to dry areas, massage into skin, and allow to absorb.
Website and/or Social Media Channels + Editorial pitch
Instagram : icure.cosmetics.global
Packaging Materials
Pump type

Timeline

29 October 2025

Platform Opening

11 February 2026

Deadline to purchase contest participation

13 February 2026

Entries closing

12 March 2026

Finalists Announcement

23 March 2026

Deadline for Receiving Products

27 March 2026

Awards Ceremony
Winners Announcement