ExoCoBio Inc.

ASCEplus® Pro - EXOMIST-W

EXOMIST-W is a rose exosome-based feminine care mist, which applies biotechnology to intimate wellness. Addressing intimate area dryness, temporary dehydration caused by physical friction or external stress, and sensitive or easily irritated skin, the spray supports moisture retention in delicate skin areas, helping to maintain a comfortable, refreshed skin condition. The mist employs lyophilized rose-derived EV technology, or EXO-RSC™, a freeze-dried stabilization process that preserves the rose exosomes’ bioactive signaling activity until activation. This ensures the exosomes’ potency, stability, and freshness prior to mixing. And the EXOCAPSULE® Dual-Activation System is a separate capsule-and-solution format that maintains the ingredients’ integrity before use. To use, the EXOCAPSULE®-W is mixed into the formula immediately before first use and shaken gently to activate the lyophilized rose-derived extra vesicles. In tests, the product showed a 150.253% improvement in skin hydration immediately after use, and a 74.390% improvement in skin soothing after four weeks of use.

Hall (Pavilion) and Stand Number: Hall 30 - Stand B77

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This product is a finalist in the category Personal Care & Body Care Products of Cosmoprof 2026

Product Description (Function, Benefits, and Target Consumer)

Launch Date (First worldwide launch must have been launched within 12 months prior to the event). Date (Month/Day/Year)

11.12.2025

Retail Price & Fill Sizes

Regular size / $45 / 50 ml+20 mg

Product Innovation

EXOMIST-W is the first rose exosome-based feminine care mist, bridging biotechnology and intimate wellness. Its 360° spray technology ensures ease of use at any angle, while the leave-in, no-rinse format sets a new standard of convenience. Unlike conventional feminine care washes or wipes, it delivers clinically validated hydration and soothing benefits in a safe, portable format. This innovation addresses a significant unmet need in personal care, offering women both discretion and efficacy.

Product Claims & Benefits

Skin Type: Suitable for delicate and sensitive intimate skin Suitable for daily use Dermatologically tested (HRIPT & Sensitization Test completed) Primary Concerns - Intimate area dryness - Temporary dehydration caused by physical friction or external stress - Discomfort or tightness before/after menstruation or exercise - Sensitive or easily irritated skin Clinical Performance - 150.253% improvement in skin hydration immediately after use - 74.390% improvement in skin soothing effect - Clinically shown to provide immediate temporary hydration after physical stimulation - No irritation observed in HRIPT and sensitization testing Functional Benefits - Supports moisture retention in delicate skin areas - Helps maintain a comfortable, refreshed skin condition - Provides non-rinse, leave-on hydration care Sensory Benefits - Lightweight, non-sticky mist - 360° leak-free spray for easy application - Soft rose scent with silky finish

Research, Clinical Tests & Trials Results (Safety & Dermatological)

P&K Skin Research Center: Human Repeat Insult Patch Test (HRIPT) & Sensitization Test
- Result: No irritation observed / No sensitization reaction
- No adverse effects reported during application.

Immediate Hydration Improvement (Single Use Clinical Study)
- Result: 150.253% improvement in skin hydration immediately after use
- Confirms rapid moisture delivery following external physical stimulation (tape stripping model).

Soothing Effect on Physically Irritated Skin (4-week evaluation)
- Result: 74.390% improvement in skin soothing effect
- Demonstrated improvement in temporary irritation caused by external physical stress.

Certifications, Patents & Regulatory Compliance

Certifications - CPNP Registered (EU Cosmetic Products Notification Portal) - Manufactured in a GMP-certified production facility (Cosmetic GMP compliance) - FSC-certified packaging components (paper-based materials) - No Animal Testing (cruelty-free commitment) Patents - 75+ Patent Applications / Registrations (Global Portfolio) KR 10-2058444, KR 10-2261434, KR 10-2341932, US 11,690,797, EP 3815675 (EU), JP 2022-565928, etc Patent portfolio covers exosome isolation, purification technology, and formulation stabilization systems. Scientific Publications - 53+ peer-reviewed publications related to exosome research and regenerative biotechnology. Regulatory Compliance - Registered under CPNP (European Union) - Registered under MOCRA

Ingredients List & Formulation (Mandatory, if not specified disqualification from the contest)

INGREDIENTS - 1: EXOCAPSULE-W Rosa Damascena Callus Extracellular Vesicles, Mannitol, Trehalose, Sodium Hyaluronate, Potassium Chloride, Ascorbic Acid, Magne- sium Sulfate, sh-Oligopeptide-21) , Glutathione, Serine, sh-Oligo- peptide-1, Cyanocobalamin, Methionine, Nicotinamide Adenine Dinucleotide, sh-Polypeptide-1, sh-Polypeptide-9, sh-Polypepti- de-3, sh-Polypeptide-76, sh-Polypeptide-59, Coenzyme A, Acetyl Hexapeptide-8, Nonapeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Disodium Flavine Adenine Dinucleotide, Copper Tripeptide-1, Palmitoyl Pentapeptide-4 INGREDIENTS - 2: ExoMist-W (Dew-Formula) Aqua (Water), Butylene Glycol, Glycerin, Niacinamide, Propanediol, 1,2-Hexanediol, Butyrospermum Parkii (Shea) Butter, Olea Europaea (Olive) Fruit Oil, Caprylic/Capric Triglyceride, Squalane, Hydrogenated Lecithin, Betaine, Polyglyceryl-10 Laurate, Parfum (Fragrance), Polygl- yceryl-4 Laurate, Disodium EDTA, Ethylhexylglycerin, Caprylyl Glycol, Adenosine, Caprylyl/Capryl Glucoside, Ceramide NP, Cholesterol, Phytosphingosine, Coccinia Indica Fruit Extract, Eclipta Prostrata Extract, Theobroma Cacao (Cocoa) Fruit Powder, Sodium Citrate, Citric Acid, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4

Technology Features

Lyophilized Rose-Derived EV Technology (EXO-RSC™) - Freeze-dried stabilization preserves bioactive signaling activity until activation. - Ensures potency, stability, and freshness prior to mixing. EXOCAPSULE® Dual-Activation System - Separate capsule-and-solution format maintains ingredient integrity before use. - Hygienic single-mix activation reduces contamination risk. - Precision dosing supports consistent performance. 360° Leak-Free Spray Design - Allows application from any angle, including inverted use. - Designed for discreet, ergonomic, and targeted application. Leave-On Mist Delivery System - Ultra-lightweight, non-sticky formula suitable for delicate skin areas. - Fast absorption without residue or rinsing requirement.

Sustainability List of Certifications

- FSC Certified Packaging (paper-based components) - No Animal Testing (cruelty-free commitment; documentation available upon request) - Packaging Responsibility Paper materials sourced with chain-of-custody standards (FSC) to support responsible forestry practices - Ongoing Sustainability Development Continuous evaluation of packaging materials and production efficiency to reduce environmental impact Responsible Manufacturing Standards - Produced under cosmetic GMP-compliant manufacturing environments with strict quality and safety controls.

How to use it

1. Open Formula 1 (EXOCAPSULE®-W) and mix into Formula 2 immediately before first use. 2. Shake gently to activate the lyophilized Rose-derived EVs. 3. Spray directly onto the external intimate area or targeted delicate skin area. 4. Allow the product to absorb naturally; no rinsing required. - Use 1–2 times daily (morning and/or evening), or as needed. - Recommended for use before or after menstruation, exercise, or prolonged activity. - For optimal potency, use within 3 weeks after activation.

Market Positioning & Distribution Markets

Market Positioning - Clinic-level exosome skincare designed for at-home use - Positioned between professional dermatology treatments and premium daily skincare - Targets consumers seeking visible results without in-clinic procedures Distribution Channels - Dermatology clinics and aesthetic clinics - Professional skincare distributors - Premium e-commerce platforms and global online marketplaces Current Distribution Markets - Asia (including Korea and Japan) Desired Distribution Markets - Europe - Middle East - North America - Expanded Asia-Pacific regions

Website and/or Social Media Channels + Editorial pitch

Official Website: http://www.exocobio.com/ Official Ins Account: @exocobio.official, @asceplus.pro_global @asceplus_pro.jp Youtube Channel: ExoCoBio.Inc Facebook: ExoCoBio The Red(Xiaohongshu): ExoCoBio官方 Our digital platforms focus on delivering science-based education, clinical insights, and real-world results related to exosome technology. Content includes dermatologist perspectives, clinical data visualization, product education, and global event highlights. Through multilingual communication and region-specific channels, we ensure accessibility across professional and consumer audiences. This integrated digital ecosystem strengthens credibility, supports informed skincare decisions, and reinforces ExoCoBio’s leadership in exosome-driven dermo-cosmetics.

Timeline

29 October 2025

Platform Opening

11 February 2026

Deadline to purchase contest participation

13 February 2026

Entries closing

12 March 2026

Finalists Announcement

23 March 2026

Deadline for Receiving Products

27 March 2026

Awards Ceremony
Winners Announcement

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