This product is a finalist in the category Skin Care Products of Cosmoprof 2026
Product Description (Function, Benefits, and Target Consumer)
Offering a non-invasive alternative to micro-needling, this cream employs bioengineered spicules that deliver micro-stimulation to the skin without trauma. The formula contains four million bio-engineered spicules, with these micro-crystalline structures designed to create transient epidermal micro-channels that enhance the penetration of actives. Those actives include 2% ElettroLift Peptide, which delivers a face-lifting effect comparable to microcurrent devices. Inspired by electrical stimulation, the peptide acts on both skin and facial muscles, with in vitro tests on the ingredient demonstrating increased MBNL1 production, improved fibronectin EDA synthesis, and enhanced collagen contraction, all of which support a firmer and more defined appearance. The peptide is liposome-encapsulated to enhance penetration, stabilize its structure, preserve activity, and promote a gradual, targeted release to skin tissues. This delivery overcomes mature skin’s reduced metabolic responsiveness, to support deeper and longer-lasting skin benefits.
Launch Date (First worldwide launch must have been launched within 12 months prior to the event). Date (Month/Day/Year)
10/06/2025
Retail Price & Fill Sizes
Regular size / 50 ml / € 132,00
Product Innovation
The innovation is that this product is a cosmetic, non-invasive alternative to traditional micro-needling. Research is the first MADE IN ITALY line to introduce a cosmetic active ingredient that induces nociception in a targeted, non-injurious way: Bioengineered Spicules deliver calibrated micro-stimulation without trauma. The Spicules activate neuro-sensory receptors to trigger repair and regeneration pathways without skin injury. This Micro-Needling effect is combined with a Deep Delivery System, a liposomal technology that enhances diffusion of active ingredients within skin cells. Formulas include biotech, biomimetic and DNA-protecting molecules and peptides selected for targeted skin signaling.
Product Claims & Benefits
4 million Bio-engineered vegan Spicules: microscopic needle-shaped structures that induce controlled, non-injurious micro-stimulation through cutaneous nociception. When the skin comes into contact with the Spicules, a mild and controlled inflammatory response is triggered, stimulating:
• Neurosensory signals that promote repair.
• Enhanced microcirculation, improving the delivery of oxygen and nutrients.
• Metabolic activation at the cellular level.
• Stimulation of keratinocytes for improved epidermal renewal.
• Fibroblast response, which promotes collagen and elastin synthesis.
• Increased permeability, which improves the absorption of active ingredients.
During application, the product provides an immediate sensorial perception of activity: a gentle tingling sensation that reflects the ongoing micro-stimulation process.
Concerns addressed: sagging, physiological and structural aging, reduced tissue cohesion, deep wrinkles, loss of firmness and elasticity.
Anti-aging strategy: supports long-term skin functionality, fights cellular senescence (zombie cells), provides resilience and structural integrity.
Deep Delivery System: liposomal technology designed to maximize active ingredient diffusion within skin cells.
Safety & compliance: Non-invasive, 0% downtime, 100% skin tolerance; fully suitable for professional aesthetic practice.
Visible performance: progressively improves firmness, density and skin integrity for a global rejuvenating effect.
Clinically proven efficacy and dermatologically tested under certified laboratory conditions.
Research, Clinical Tests & Trials Results (Safety & Dermatological)
A clinical study under Dermatological supervision was conducted to evaluate dermatological tolerability, pleasantness of use and perceived efficacy of the Chronos face homecare treatment (face cream + face treatment) in subjects showing visible signs of facial ageing. The study followed the framework of Commission Regulation (EU) No 655/2013, with standardized procedures under an ISO 9001 Quality Management System, and assessments performed under controlled temperature and humidity conditions.
Study design:
• Sample size: 20 female subjects.
• Age range: 45–65 years.
• Skin profile at baseline: mild/moderate ageing signs, mild/moderate skin slackness, loss of tonicity, dullness, slight/moderate wrinkles.
• Duration: 28 days (T0–T28), home use according to instructions.
• Evaluations: clinical dermatological assessment at T0 and T28, digital pictures at T0 and T28, plus a self-assessment questionnaire.
Safety / Dermatological tolerability:
• Dermatologically tested: the product was well tolerated and safe under the test conditions.
Top 3 most relevant perceived efficacy results:
• 95% noticed that the face appeared more lifted and smoother immediately after application.
• 95% found the face noticeably firmer after 28 days.
• 80% noticed visibly younger-looking skin with an overall improvement in signs of ageing after 1 week of use.
Supporting evidence: high-quality before-and-after digital photographs (T0 vs T28) are available to visually document the achieved results.
Chronoplex Cream contains:
4 million Bio-engineered Spicules (Calcium Aluminum Borosilicate): micro-crystalline structures designed to create transient epidermal micro-channels that enhance the penetration of ElettroLift Peptide and other actives. 2% ElettroLift Peptide: an innovative peptide developed to deliver a face lifting effect comparable to microcurrent devices. Inspired by electrical stimulation, it acts on two levels: skin and facial muscles. In vitro tests showed increased MBNL1 production, improved fibronectin EDA synthesis and enhanced collagen contraction, supporting a firmer and more defined appearance. In vivo volunteer studies highlighted visible improvements after 28 days, with a significant lifting effect on eyebrows, eyelids and cheeks.
Certifications, Patents & Regulatory Compliance
Research ensures the highest standards of safety, quality and regulatory compliance through the following certifications and alignments:
• ISO 22716 (GMP) Certified: compliance with International Good Manufacturing Practices covering manufacturing, filling, packaging, storage and distribution.
• VeganOK Certified: Chronoplex Cream is certified 100% free from animal-derived ingredients, meeting a globally recognized ethical standard.
• Dermatologically Tested: product safety and skin tolerability assessed under dermatological supervision to support high biocompatibility, including on reactive or intolerant skin.
• Cosmetic Micro-Needling compliance: Research Micro-Needling is a non-invasive cosmetic approach, designed to be fully aligned with cosmetic regulatory requirements and suitable for professional aesthetic practice.
Ingredients List & Formulation (Mandatory, if not specified disqualification from the contest)
Hero ingredients & key technologies:
• ElettroLift Peptide 2% (Tetrapeptide-1): next-generation biomimetic peptide developed to simulate microcurrent-like stimulation, supporting facial muscle tone and helping counteract structural sagging in chronoaging. The peptide is liposome-encapsulated to enhance transcutaneous penetration, stabilize its structure, preserve activity and promote a gradual, targeted release to skin tissues. This delivery approach is especially relevant for mature skin, often characterized by reduced metabolic responsiveness, supporting a deeper and longer-lasting myostructuring effect and improved definition and facial volume support.
• Bioengineered Spicules 1.5% (Calcium Aluminum Borosilicate): micro-crystalline structures designed to create transient epidermal micro-channels that enhance the penetration of ElettroLift Peptide and other actives. Spicules provide a controlled density of 4,125,000 spicules in 50 ml, corresponding to 82,500 spicules per ml, delivering an intense yet controlled stimulating action. They support endogenous processes linked to neocollagenesis and cellular turnover, improving firmness, elasticity and tissue resistance without inducing inflammatory stress.
VeganOK Certified: 100% free from animal-derived ingredients.
• Fragrance-free.
• Colorant-free.
Full INCI (Ingredients)
Aqua/Water/Eau, Dicaprylyl Ether, Glycerin, Mangifera Indica (Mango) Seed Butter, Caprylic/Capric Triglyceride, Camellia Japonica Seed Oil, Adansonia Digitata Seed Oil, Calcium Aluminum Borosilicate, Tetrapeptide-1, Polyacrylate-13, Polyglyceryl-3 Cocoate, Propanediol, Polyisobutene, Hydrogenated Lecithin, Inulin Lauryl Carbamate, Tocopherol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Lecithin, Phenoxyethanol, Caprylyl Glycol, Helianthus Annuus (Sunflower) Seed Oil, Disodium EDTA, Polysorbate 20, Sodium Hydroxide, Sorbitan Isostearate.
Technology Features
• Scientific transparency on-pack: each packaging clearly states the real percentage of active ingredients and the exact concentration of bioengineered spicules, providing a technical, verifiable language that reinforces scientific credibility in professional skincare.
• Airless jar technology: protects the formula from external contamination and oxidation, maintaining product hygiene and integrity throughout use. Airless dispensing allows the cream to be used until the last drop, minimizing internal residue and waste.
• Controlled dosage per application: the dispenser delivers a pre-calibrated amount, designed to match one application dose.
• Design uniqueness: premium aesthetic with a distinctive 3D visual effect achieved through internal silk-screen printing, protecting the graphics and enhancing depth and refinement.
• Professional user experience: clean handling, precise dispensing and high sensorial perception aligned with advanced anti-ageing protocols.
Sustainability List of Certifications
• VeganOK Certified: certified compliance with VeganOK standards, confirming the absence of animal-derived ingredients in the formula and alignment with ethical requirements.
• ISO 22716 (GMP) Certified: certified Good Manufacturing Practices ensuring controlled, traceable and quality-driven production processes across manufacturing, filling and packaging.
• Plastic reduction by design: the product is intentionally distributed without plastic cellophane overwrapping, eliminating unnecessary single-use plastic and reducing packaging waste at point of sale.
• Material-efficiency in use: the airless packaging supports complete product dispensing, helping minimize residual waste and improving consumption efficiency.
How to use it
• Apply morning and evening on clean, dry skin.
• Dispense and spread evenly over the face, massaging until absorbed.
• A characteristic tingling sensation may occur during and after application: these are the Spicules in action.
• Designed as homecare to extend and intensify the professional Chronos in-Institute treatment.
• Can be used alone as a daily anti-aging face cream. Daily cosmetic micro-needling provides a progressive regenerative stimulus and longevity-oriented renewal.
• Suitable as supportive skincare after professional aesthetic procedures such as fillers, biostimulants, PRP/polynucleotides, botulinum toxin, radiofrequency or HIFU, following practitioner guidance.
Market Positioning & Distribution Markets
• Positioning: Research is positioned as a premium professional skincare system inspired by clinical science, with measurable and proven results. The Chronoplex line targets physiological and structural ageing through high-performance actives, an advanced delivery system for optimal molecule penetration.
• Retail & digital presence: Chronoplex Cream is primarily distributed through Research Accredited Institutes, where our "Dermotechnologists®" provide personalized skin consultations. It is also positioned as a high-performance post-procedure retail companion within the medical-aesthetic channel, supporting skin recovery and visible results after in-clinic professional treatments. It is also available at our Flagship Store “Rhea Concept Store”, in Bologna (Italy), and through our official e-commerce platforms.
• Current Distribution Markets: The product is currently available in Italy, Austria, Switzerland and Armenia.
• Desired Distribution Markets: Our Export Sales Department is actively focusing on expanding Research’s global footprint. Our primary targets for future distribution of both retail products and professional treatments are the Middle East and Asia-Pacific regions.
Website and/or Social Media Channels + Editorial pitch
Editorial Pitch: Chronoplex Cream performs a non-invasive cosmetic micro-needling effect to fight skin aging and zombie cells: lifted, smoother, firmer-looking skin from the first use.
Website: www.researchskin.com
Instagram: @researchskin.official – Professional education, protocol insights and Research technology highlights.
Facebook: Research Skin – Updates on product launches and advanced aesthetic skincare content.
LinkedIn: Rhea Cosmetics – Corporate updates, R&D vision and international distribution growth.
Chronoplex Cream has a dedicated product page featuring full information, hero technologies and key clinical results in a clear, professional tone of voice. The page is supported by high-quality before-and-after images from clinical testing and includes a technical and scientific video explaining the Chronos protocol. Users can request personalized guidance through an online consultation/chat. Social communication includes educational posts, reels and UGC-driven content focused on visible performance, skin longevity and professional positioning. Dedicated materials (social posts, short videos and WhatsApp-ready educational messages) are made available for accredited institutes to share directly with clients.
