This product is a finalist in the category Innovation Technology of Cosmopack 2026
Product Description (No Prototypes accepted)
Chrono-Dot is a lightweight, nano-technology booster serum that offers the time-optimized release of active ingredients. The formula can be mixed into skin care or make-up or applied alone, and acts as a delivery platform that programs when actives perform, as its microfluidic fabrication unlocks poorly soluble ingredients while elevating their stability. Chrono Dot™ is infused with two nano carrier types: one triggers the rapid release of actives and completes delivery within three hours, while the other initiates the gradual release of actives, sustaining their delivery for up to 72 hours. The formula, which also spotlights encapsulation within polymer shells, additionally stabilizes actives while ensuring its compatibility across products. Chrono-Dot™’s ingredients include antioxidant resveratrol; PLGA, a lactic acid-glycolic acid copolymer; nanoparticles composed of a biodegradable sustained-release polymer; nano emulsion carriers; and sodium hyaluronate for hydration. In tests, the formula demonstrated a 4.36 times higher penetration efficiency compared to liposomes.
Launch Worldwide Date (First worldwide launch must have been launched within 12 months prior to the event). Date (Month/Day/Year)
03/20/2026 (Planned at Cosmoprof Worldwide Bologna 2026)
Product Innovation
Chrono-Dot™ is not just a delivery technology. It is a next generation release architecture that engineers the time of active efficacy.
•Ingredient Innovation
- Enables stable delivery of difficult actives while protecting protency.
•Formula Innovation
- Dual-carrier system ensures rapid onset and sustained efficacy through time-engineered release.
•Packaging Innovation
- Reduces reliance on complex packaging, enabling flexible designs and faster commercialization.
•User Experience Innovation- Delivers long-lasting efficacy beyond application, enhancing user satisfaction and performance.
• Platform Versatility - Expands across diverse actives, formats and integrated solutions.
Claims & Benefits
1. Chrono Controlled Release System :
Chrono Dot™ integrates two nano carrier types engineered with distinct degradation kinetics. By tuning biodegradable polymer molecular weights, differentiated release profiles are achieved. One carrier triggers rapid release immediately after skin absorption and completes delivery within approximately three hours. The second initiates gradual release and sustains delivery for up to 72 hours. Through optimized ratio design Chrono Dot™ enables strong initial output while maintaining controlled levels over time creating a release curve designed for continuous skincare performance.
2. Stabilization System for Poorly Soluble and Labile Actives :
Produced via ultra precise microfluidics, Chrono Dot™ is optimized for active protection. The process allows accurate, reproducible control of loading capacity. Encapsulation within polymer shells markedly improves physicochemical and oxidative stability versus conventional formulations. The platform stabilizes actives while ensuring compatibility across products nano carriers can encapsulate about 20% resveratrol with high integrity.
3. Enhanced Skin Delivery efficacy : The hybrid nano carrier system penetrates deeper into the skin compared to traditional delivery systems providing both immediate benefits and sustained care for enhanced efficacy.
4. Skin Booster Functionality : Easily integrates with various skincare products enhancing their efficacy by delivering actives with precision and sustained.
Research, Clinical Tests & Trials Results (Safety & Dermatological)
• Release behavior tests for nanoemulsion, PLGA nanoparticles, and Chrono-Dot to validate its dual-phase system in improving delivery consistency compared to single-phase systems.
• Stability tests for Chrono-Dot at 25°C and 40°C over 3 months to evaluate potency retention.
• Skin penetration test using Raman spectroscopy: The degree of skin penetration of liposomes and Chrono-Dot, on forearms of five women,
• Chemical membrane tests showed penetration rates after 24 hours:
• Skin efficacy test via in-vitro test by measuring gene expression levels related to skin elasticity in cultured cells.
[ Key Results] : 1. Release Test - Independent release characteristics over 24 hours demonstrated: -Nanoemulsion: 71.96% (0–3h), 8.48% (3–6h), 5.74% (6–12h), 1.77% (12–24h). -PLGA Nanoparticles: 15.5% (0–3h), 31.46% (3–6h), 21.61% (6–12h), 17.99% (12–24h). -Chrono-Dot: Achieved release rates of 26.79% (0–3h), 26.86% (3–6h), 18.44% (6–12h), and 14.47% (12–24h), ensuring consistent delivery across 24 hours.
2. Potency / Stability - Chrono-Dot retained over 90% potency after 3 months under 25°C and 40°C conditions, confirming its ability to protect active ingredients.
3. Penetration Efficiency - Chemical membrane tests showed penetration rates after 24 hours.
Efficiency - Chrono-Dot (76.09%) demonstrated 4.36 times higher penetration efficiency than liposomes (17.45%) in the chemical membrane test and approximately four times higher penetration in Raman spectroscopy analysis.
. Elastic Efficiency - Resveratrol-loaded Chrono-Dot increased elasticity-related gene expression by 52%, compared to 17% for liposomes, showing 300% higher efficiency.
• Conclusion : Chrono-Dot sets a new standard in delivery systems, outperforming liposomes in penetration efficiency, elastic efficacy, and delivery consistency, making it a groundbreaking solution for active ingredient delivery.
Certifications, Patents & Regulatory Compliance
At Chrono-Dot, we are actively working towards obtaining essential global certifications to ensure product safety, efficacy, and regulatory compliance. While some certifications are still in progress, we have successfully secured key patents for our time programmed delivery technology, reinforcing our commitment to innovation and scientific excellence. [Patents]
• Registered Patent : No. 10-2024-0119732 (South Korea)
• Registered Patent : No. 10-2827326 (South Korea)
[Certification(In progress)]
• EU Cosmetics Regulation We are actively working to meet the requirements of the EU Cosmetics Regulation ensuring product safety and quality for entry into the European market. • U S FDA MOCRA We are preparing to comply with FDA and MOCRA standards focusing on product safety labeling and registration for the U S market. • China’s NMPA We are progressing through the registration and certification process to meet China’s NMPA regulations including product testing and documentation. • Brazil’s ANVISA. We are working to fulfill Brazil’s ANVISA requirements ensuring compliance with safety evaluations and regulatory standards for the Brazilian market. • Japan’s PMD Act We are preparing to meet Japan’s PMD Act standards focusing on product registration and safety evaluations for entry into the Japanese market.
Ingredients List & Formulation (Mandatory, if not specified disqualification from the contest)
[Hero Ingredients]
• Resveratrol – high-dose antioxidant actives
• PLGA (Lactic acid/Glycolic acid copolymer) nanoparitlces – biodegradable sustained-release polymer
• Nanoemulsion carriers – burst-phase activation
• Sodium Hyaluronate – hydration support
[Formulation]
- The formulation is a lightweight booster serum engineered with advanced nano-technology to ensure precise, time-optimized release of active ingredients for targeted and sustained efficacy. Our formula is carefully crafted to prioritize safety, sustainability, and skin health. We are committed to creating products that are free from parabens, sulfates, artificial fragrances, animal-derived ingredients, and non-biodegradable microplastics. By eliminating these potentially harmful or environmentally damaging components, we ensure that our formulations are clean, ethical, and eco-friendly. We continuously strive to improve every aspect of our formulas, using advanced technologies and sustainable practices to deliver effective solutions that align with our values. Our dedication to creating high-quality, responsible skincare reflects our mission to support both your skin and the planet.
[Full Ingredients lists]
- Water, Glycerine, Lactic acid/Glycolic acid copolymer (PLGA), Polyvinyl Alcohol, Sodium Hyaluronate, Resveratrol, 1,2-Hexanediol, Ethylhexylglycerin, Octyldodeceth-16
Technology Features
• Packaging Materials and Functionality: Eco-friendly, recyclable, and biodegradable materials. Tear-drop shaped packaging for precise dosing and minimal waste. Lightweight design to reduce carbon emissions during transportation.
• Design Uniqueness: Unique dual-phase delivery system combining nanoemulsion (initial release) and PLGA nanoparticles (sustained release). Control of molecular weight of biodegradable polymer for optimized penetration and release timing. Precision dispensing packaging to maximize efficiency and minimize overuse.
• Sustainable Components/Production Process: Biodegradable PLGA-based carriers with tailored molecular weights. Microfluidics manufacturing process for high stability and reduced resource consumption. Transitioning to refillable packaging and sourcing Fair Trade ingredients.
Chrono-Dot™ integrates sustainability, innovation, and advanced delivery mechanisms to redefine skincare technology.
Sustainability List of Certifications
We strive to use vegan-friendly, plant-based ingredients that can adhere to certifications such as COSMOS, Ecocert, and USDA Organic. Our goal is to ensure all formulations remain cruelty-free and are developed using safe, science-backed methods without animal-derived components. •Biodegradable Packaging Materials - Packaging is made from biodegradable polymers, reducing environmental impact and waste. •Recyclable Design - Tear-drop packaging is fully recyclable, supporting circular economy principles. •Minimal Waste Approach -Compact design minimizes material usage and reduces carbon emissions during transportation. •Certifications Under Review - Biodegradability OECD standards. Nordic Swan Ecolabel and EU Ecolabel for sustainable packaging practices. Certified B Corporation (B Corp) for ethical and sustainable business operations. •Future Goals -Designed for minimal material use and full recyclability. -Sourcing Fair Trade and Fair for Life-certified ingredients. -Collaboration with sustainability experts to achieve additional certifications.
How to use it
Chrono-Dot is designed to seamlessly integrate into your daily skincare routine. - Use 1-2 drops by mixing it with your favorite skincare or makeup products, such as serums, moisturizers, or foundations, to enhance their efficacy. Alternatively, apply it directly to your skin for targeted care. For optimal results, use the product once in the morning and once at night. The innovative stepwise release mechanism ensures active ingredients remain effective for up to 24 hours. This versatile formula suits all skin types and easily fits into any skincare routine.
Website and/or Social Media Channels + Editorial pitch
- Our official website and social media channels are currently under preparation and will be launched on March 20, 2026, in conjunction with the official product launch.
[Editorial Pitch] - An innovative serum with advanced dual-phase releasing technology, delivering active ingredients deep into the skin for maximum, long-lasting efficacy.
Packaging Materials
-Materials: Eco-friendly, recyclable, and biodegradable materials, free from microplastics. -Special Shapes: Unique tear-drop shape designed for precise dosing and minimal product waste. -Printing Techniques: Advanced printing methods that reduce ink usage while maintaining high-quality branding. -Sustainable features : Lightweight design to lower carbon emissions during transportation. Actively transitioning to fully sustainable materials and exploring refillable options to extend product life cycles. Packaging aligns with certifications like EU Ecolabel and Nordic Swan, showcasing our commitment to reducing waste and environmental impact. Chrono-Dot’s packaging combines functionality, sustainability, and innovation to support mindful consumption and eco-conscious practices.
